郑可  
性    别:
专业名称:
材料科学与工程系
研究方向:
生物质纳米材料
技术职务:
副教授
行政职务:
办公电话:
办公传真:
 E-mail:
zhengkeahau.edu.cn
实验室主页:
通讯地址:
邮政编码:
教育背景:
2017.10–2019.10  中国科学院上海微系统与信息技术研究所、上海科技大学,博士后    合作导师:凌盛杰
2013.6–2017.7  南京林业大学林产化学加工工程系,博士    导师:范一民
2014.6–2015.7.  Tufts University生物医学工程系,访问学者    导师:David L. Kaplan
2011.9–2013.7  南京林业大学林产化学加工工程系,硕士    导师:余世袁
2007.9–2011.7  南京林业大学生物工程系,学士
 
科研背景:
1、天然生物材料的结构解析及仿生材料设计、开发
天然高分子材料中多层级介观结构解析,例如纤维素、甲壳素、蚕丝、蜘蛛丝等材料的结构解析,探索其介观结构对宏观力学行为的影响;以此为基础,仿生构筑具有类似结构的纤维状材料用于各类仿生材料应用。
2、基于同步辐射光源技术开发,及应用于材料解析和辅助设计
利用同步辐射光源技术(包括红外、X射线技术等)对天然生物高分子材料的结构解析;以及基于此的仿生生物纳米材料的设计、开发及应用;尤其是以动物丝、纤维素、几丁质等介观结构为基础的纳米材料仿生制备与应用开发;具有丰富的同步辐射光源(合肥、上海光源)项目申请和实际操作经验。
3、生物纳米材料的设计、组装、制备和调控
天然生物基纳米材料的结构和层级组装行为分析研究,通过“部分溶解和物理分散”方式,从动物丝中剥离出了全尺寸分布的丝介观结构:包括了从微米级纤维、纳米纤维直至纳米颗粒等不同形貌和尺寸的介观结构。所剥离出的丝介观结构具有尺寸可调、分布均匀、高力学模量、良好的再分散性以及可加工性等优势,并可应用于如污水处理、有机循溶剂回收,纸传感器,纳米农药等领域。
4、生物医用材料开发应用
动物丝蛋白材料的改性,以及性能表征。针对性优化并制备基于动物丝蛋白的生物医学及组织工程材料,应用于骨修复等领域。
 
研究兴趣:
方向1:天然高分子材料解析及仿生构筑
(1)同步辐射技术结合原子力-红外、高分辨电镜技术等先进表征手段,对天然纺丝机理及过程的深入解析,并以此为基础指导构筑蛋白基多层级材料。
(2)天然蛋白/多肽界面自组装行为原位表征及机理研究,不同界面环境对组装体结构、形貌影响探究。
(3)利用合成生物学技术“从头设计”并制备蛋白/多肽序列,并调控其多尺度自组装过程,用以满足构筑特定功能性材料需求。
 
方向2:生物基大分子中纳米结构提取及应用
(1)农林及附属产业废弃物中生物质纳米结构提取与应用
(2)动物丝介观结构改性及于环境领域应用
 主讲课程
 
 科研情况
主要研究成果:
 
(1) Ke Zheng, Jiajia Zhong, Zeming Qi, Shengjie Ling*, David L. Kaplan*. Isolation of Silk Mesostructures for Electronic and Environmental Applications. Advanced Functional Materials, 2018, DOI: 10.1002/adfm.201806380. (IF=13.325)
 
(2) Ke Zheng, Ying Chen, Wenwen Huang, Yinan Lin, David L. Kaplan*, Yimin Fan*. Chemically Functionalized Silk for Human Bone Marrow-Derived Mesenchymal Stem Cells Proliferation and Differentiation, ACS Applied Materials & Interfaces, 2016, 8(23): 14406-14413. (IF=8.097)
 
(3) Ke Zheng, Juan Yu, Wenwen Zhang, Xun Li, Yimin Fan*, David L. Kaplan. Self-Assembling Oxidized Silk Fibroin Nanofibrils with Controllable Fractal Dimension. Journal of Materials Chemistry B, 2018, DOI: 10.1039/c8tb00567b. (IF=4.776)
 
(4) Ke Zheng, Shengjie Ling*, De Novo Design of Recombinant Spider Silk Proteins for Material Applications. Biotechnology Journal, 2018, 1700753. (IF=3.507)
 
(5) Ke Zheng, Yanlei Hu, Wenwen Zhang, Shengjie Ling*, Yimin Fan*. Oxidizing and Nano-dispersing the Natural Silk Fibers. Nanoscale research letters, 2019, 14(1): 250. (IF=3.159)
 
(6) Shengjie Ling*, Wenshuai Chen, Yimin Fan, Ke Zheng, Kai Jin, Yu Haipeng, Markus J. Buehler*, David L. Kaplan*, Biopolymer Nanofibrils: Structure, Modeling, Preparation, and Applications, Progress in Polymer Science, 2018, DOI: 10.1016/j.progpolymsci.2018.06.004. (IF=24.558)
 
(7) Ke Zheng, Jing Ren, Yawen Liu, Shengjie Ling*. Synergetic integration of computer-aided design, experimental synthesis, and self-assembly for the rational design of peptide/protein nanofibrils, Elsevier S&T Books, 2019.
 
(8) Wenwen Zhang# and Chao Ye#, Ke Zheng, Jiajia ZhongYuzhao TangYimin Fan*Markus J. Buehler*Shengjie Ling*, and David L. Kaplan* Tensan Silk Inspired Hierarchical Fibers for Smart Textile Applications. ACS Nano, 2018, DOI: 10.1021/acsnano.8b02430. (IF=13.709)
 
(9) Shengjie Ling, Kai Jin, Zhao Qin, Chunmei Li, Ke Zheng, Yanyan Zhao, Qi Wang, David L. Kaplan*, Markus J. Buehler*. Combining In Silico Design and Biomimetic Assembly: A New Approach for Developing High-Performance Dynamic Responsive Bio-Nanomaterials. Advanced Materials. 2018, 30(43): 1802306. (IF=21.950)
 
(10) Xin Li, Ke Zheng, Chenhuan Lai, Jia Ouyang, Qiang Yong*, Improved Itaconic Acid Production from Undetoxified Enzymatic Hydrolysate of Steam-Exploded Corn Stover using an Aspergillus terreus Mutant Generated by Atmospheric and Room Temperature Plasma. BioResources, 2016, 11(4): 9047-9058.
 
(11) Yangye Geng, Zhen Zhu*, Yingying Wang, Yiyun Wang, Shuiping Ouyang, Ke Zheng, Wenbo Ye, Yimin Fan, Zixin Wang, Dejing Pan. Multiplexing Microelectrodes for Dielectrophoretic Manipulation and Electrical Impedance Measurement of Single Particles and Cells in a Microfluidic Device. Electrophoresis, 2019, DOI 10.1002/elps.201800433.
 
(12) Liang Liu, Rong Wang, Juan Yu, Jie Jiang, Ke Zheng, Lijiang Hu, Zhiguo Wang, Yimin Fan*, Robust Self-Standing Chitin Nanofiber/Nanowhisker Hydrogels with Designed Surface Charges and Ultralow Mass Content via Gas Phase Coagulation. Biomacromolecules, 2016, 17(11): 3773-3781.
 
(13) Yan Zhang, Jie Jiang, Liang Liu, Ke Zheng, Shiyuan Yu, Yimin Fan*, Preparation, Assessment, and Comparison of α-chitin Nano-fiber Films with Different Surface Charges. Nanoscale Research Letters, 2015, 10(1): 226.
 
(14) Liang Liu, Hechan Lv, Jie Jiang, Ke Zheng, Wenbo Ye, Zhiguo Wang, Yimin Fan*, Reinforced Chitosan Beads by Chitin Nanofibers for The Immobilization
of β-glucosidase. RSC Advances, 2015, 5(113): 93331-93336.
 
(15) Chenhuan Lai, MaobingTu*, Zhiqiang Shi, Ke Zheng, Luis G.Olmosc, ShiyuanYu, Contrasting Effects of Hardwood and Softwood Organosolv Lignins onEnzymatic Hydrolysis of Lignocellulose. Bioresource Technology, 2014, 163: 320-327.


专利:
一种蚕丝纳米纤维分散液的制备方法   201710378698.4
 获奖情况
2017年南京林业大学校长特别奖学金
 论文论著