孙冬冬  
性    别:
单    位:
生命科学学院
专业名称:
生物制药
研究方向:
纳米药物的设计与活性研究
技术职务:
特任副教授
行政职务:
生物制药系副主任
办公电话:
办公传真:
 E-mail:
sunddwj126.com
实验室主页:
通讯地址:
安徽农业大学生命科学学院
邮政编码:
230036
孙冬冬,男,博士,硕士生导师。2013年进入安徽农业大学生命科学学院工作。主要研究方向为小分子配合物的生物活性及其调控细胞信号转导途径的功能;纳米药物的制备、缓释控制及其靶向功能的研究与应用;具有抗肿瘤、阿尔茨海默氏病、抗菌活性的化学新药研制与开发。主持国家自然科学基金青年科学基金项目、安徽省自然科学基金青年科学基金项目。在金属小分子的设计与开发,纳米修饰,分子成像以及癌症治疗领域研究有着丰富的研究经验,并取得了较好的研究成果,以第一作者身份发表SCI收录论文13余篇,其中包括Biomaterials(IF=8.4),Applied Materials&Interfaces(IF=7.1)Chemistry A European Journal(IF=5.8)和Dalton Trans(IF=4.0)等高水平学术论文。
 主讲课程
药物化学、药物分析及药事管理学。
 
 科研情况
(1)国家自然科学基金青年科学基金项目(2014-2017年)手性青霉胺纳米多肽抑制金属离子诱导的Aβ纤维化聚集及机制研究  编号:21401002  主持  25万
(2)安徽省自然科学基金青年科学基金项目(2015-2017年)  编号:1508085QB37  主持  8万
 获奖情况
安徽省道地中药材系列品种选育与应用  2016年安徽省科学技术奖三等奖 (主要项目完成人)
 论文论著
 

(1)        Dongdong Sun1, Weiwei Zhang1, Zhipeng Mou, Ying Chen, Feng Guo, Endong Yang, Weiyun Wang* Transcriptome Analysis Reveals Silver Nanoparticle-decorated Quercetin Antibacterial Molecular Mechanism. Applied Materials&Interfaces. 2017 DOI: 10.1021/acsami.7b02380Accepted.

(2)        Dongdong Sun, Yanan Liu, Qianqian Yu, Qiuying Qin, Licong Yang, Yanhui Zhou, Lanmei Chen, Jie Liu*. Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles. Biomaterials 2014, 35, 1572-1583.

(3)        Dongdong Sun, Yanan Liu, Qianqian Yu, Yanhui Zhou, Rong Zhang, Xiaojia Chen, An Hong* and Jie Liu*. The Effects of Luminescent Ruthenium(II) Polypyridyl Functionalized Selenium Nanoparticles on bFGF-induced Angiogenesis and AKT/ ERK Signaling. Biomaterials, 34 (2013) 171-180.

(4)        Dongdong Sun, Yanan Liu, Du Liu, Rong Zhang, Xicheng Yang,and Jie Liu*. Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Live Cell Imaging Studies of Chiral Ruthenium(II) Complexes. Chem. Eur. J. 2012, 18, 4285-4295.

(5)        Dongdong Sun, Rong Zhang, Fang Yuan, Du Liu, Yanhui Zhou, Wenjie Mei, and Jie Liu*. Studies on characterization, telomerase inhibitory property and G-quadruplex binding of η6-arene ruthenium complexes with 1,10-phenanthroline-derived ligands. DaltonTrans 2011;41:1734-41.

(6)        Dong-dong Sun, Wei-zhang Wang, Jian-wen Mao, Wen-jie Mei* and Jie Liu*. Imidazo 【4, 5f】【1, 10】 phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-kB pathway. Bioorg Med Chem Lett. 22 (2012) 102-105.

(7)        Dongdong Sun,Weiwei Zhang, Endong Yang, Nuan Li,Haiping Liu, Weiyun Wang*. Investigation of antibacterial activity and related mechanism of a ruthenium(II) polypyridyl complex. Inorganic Chemistry Communications. Inorganic Chemistry Communications 56 (2015) 17–21.

(8)        Dongdong Sun, Yanan Liu, Qianqian Yu, Du Liu, Yanhui Zhou, and Jie Liu*. Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNAJournal of Inorganic Biochemistry 150 (2015) 90–99.

(9)        Dongdong Sun, Weiwei Zhang, Mengting Lv, Endong Yang, Qian Zhao, Weiyun Wang*. Antibacterial activity of ruthenium(II) polypyridyl complex manipulated by membrane permeability and cell morphology. Bioorg. Med. Chem. Lett. 25 (2015) 2068–2073.

(10)     Dongdong Sun, Weiwei Zhang, Nuan Li, Endong Yang, Haiping Liu, Weiyun Wang.* Silver nanoparticles-quercetin Conjugation to siRNA against multidrug-resistant Bacillus subtilis for Effective Gene Silencing: In Vitro and in Vivo. Materials Science and Engineering C 63 (2016) 522–534.

(11)     Dongdong Sun, Nuan Li, Weiwei Zhang, Endong Yang, Zhipeng Mou, Zhiwei Zhao, Haiping Liu , Weiyun Wang*. Quercetin-loaded PLGA nanoparticles: a highly effective antibacterial agent in vitro and anti-infection application in vivo. J Nanopart Res( 2016)1 8:3-21.

(12)     Dongdong Sun, Zhipeng Mou, Nuan Li, Weiwei Zhang,Yazhe Wang, Endong Yang, Weiyun Wang*. Anti-tumor activity and mechanism of apoptosis of A549 induced by ruthenium complex【J】. J Biol Inorg Chem, 2016:1-12.

(13)     Dongdong Sun, Nuan Li, Weiwei Zhang, Zhiwei Zhao, Zhipeng Mou, Donghui Huang, Jie Liu, Weiyun Wang*. Design of PLGA- functional quercetin nanoparticles for potential use in Alzhermer’ disease Colloid Surface B.148(2016)116-129.

(14)     Dongdong Sun, Xicheng Yang, Yanan Liu, Rong Zhang, and Jie Liu Stabilization of G-Quadruplex DNA and Inhibition of Telomerase Activity by Chiral Ruthenium(II) Complexes. Submit to 11th International Symposium on Applied Bioinorganic Chemistry,   Barcelona 2011.(国际会议论文).

(15)     Dongdong Sun, Rong Zhang, Fang Yuan , Du Liu,Yanhui Zhou, Wenjie Mei,Jie Liu*. Studies on synthesis, characterizationhigh selectity and G-quadruplex binding of η6-arene ruthenium with 1,10-Phenanthroline -derived ligands. The Seventh National Conference on Chemical Biology. 8.28-8.29.2011,(第七届全国化学生物学学术会议,NanJing, China.

(16)     孙冬冬,杨永光,张蓉,袁方,周艳晖,刘杰*.【Ru(bpy)2(tip)】 2+【Ru(phen)2(tip)】 2+与人端粒DNA相互作用的性质研究。第十一届全国生物无机化学学术会议,2011916-919日,中国河北.

(17)     孙冬冬,朱梦瑶,魏雨婷,王海军,汪维云*.姜黄素修饰的纳米金棒抑制胃癌细胞SGC-7901 的作用. 《安徽农业大学学报》,2016(6):976-981.

(18)     孙冬冬,牟志鹏,李  暖,张伟伟,赵志伟,黄东辉,杨小方,汪维云*. 钌配合物【Ru(MeIm)4(4mopip)】2+稳定G-四链体对抑制肺癌细胞生长机制的研究. 安徽农业大学学报, 2016, 43(1): 1-6.