张欣  
性    别:
单    位:
生命科学学院
专业名称:
生物物理
研究方向:
天然产物化学和多肽组学
技术职务:
教授
行政职务:
办公电话:
0551-65786021
办公传真:
0551-65786021
 E-mail:
xinzhangahau.edu.cn
实验室主页:
通讯地址:
合肥市长江西路130号
邮政编码:
230036

张欣,女,博士,教授,博士生导师。毕业于吉林大学,2000年获中国科学院长春应用化学研究所硕士,2002年赴法国留学,在斯特拉斯堡第一大学(路易•巴斯德大学,Université Louis Pasteur, Strasbourg, France)药学院攻读博士学位,2005年获法国国家博士学位;2006年6月至2008年9月在美国纽约阿尔伯特•爱因斯坦医学院(Albert Einstein College of Medicine, NY, USA)分子药理系担任研究助理。2008年底回国,2009年6月起被聘为安徽农业大学生命科学学院讲席教授。在分析化学、天然产物、多肽组学等基础研究领域具有专长,科研能力强。发表SCI论文20多篇,多项研究成果具有重要的科学价值和应用前景,达到本领域国际先进水平。拥有2项国家发明专利。

 主要教学经历与成果
 主要研究领域

      1. 功能小分子结构及其生理活性的研究:分离制备天然有机功能小分子及其衍生物,研究其化学结构,并运用一系列体内体外模式生物分析相关生理活性,探讨其作用机理。
      2. 多肽组学研究:开展与植物生理、病理等性状相关的具有生物活性的多肽组学研究。

 主要科研项目

国家自然科学基金项目(21072002):植物甾醇单体氧化物的制备及其细胞毒性的研究(主持)
教育部留学回国人员科研启动基金(教外司留(2011)1568号):Δ7-植物甾醇氧化物的合成及生物效应研究(主持) 

 

 主要科研成果
 代表性论文论著
1. Lele Zhang, Minglei Yang, Junlan Gao, Shan Jin, Zhengyan Wu, Lifang Wu*, Xin Zhang*. Seasonal variation and gender pattern of phenolic and flavonoid contens in Pistacia chinensis Bunge inflorescences and leaves. Journal of Plant Physiology 2016, 191, 36-44.
 
2. Junlan Gao, Shaopeng Chen, Lele Zhang, Beijiu Cheng, An Xu*, Xin Zhang*. Evaluation of cytotoxic and apoptotic effects of individual mixed 7-ketophytosterol oxides on human intestinal carcinoma cells. Journal of Agricultural and Food Chemistry 2015, 63, 1035-1041.
 
3. Lulu He, Min Wang, Guilong Zhang, Guannan Qiu, Dongqing Cai*, Zhengyan Wu*, Xin Zhang*. Remediation of Cr(VI) contaminated soil using long duration sodium thiosulfate supported by micro-nano networks. Journal of Hazardous Materials 2015, 294, 64-69.
 
4. Guilong Zhang, Ruohong Du, Lele Zhang, Dongqing Cai, Xiao Sun, Yong Zhou, Jian Zhou, Junchao Qian, Kai Zhong, Kang Zheng, Darnell Kaigler, Wenqing Liu, Xin Zhang*, Duohong Zou*, Zhengyan Wu*. Gadolinium-doped iron oxide nanoprobe ad multifunctional bioimaging agent and drug deliver system. Advanced Functional Materials 2015, 25, 6101-6111.
 
5. Linglin Zhou, Dongqing Cai, Lulu He, Naiqin Zhong, Mei Yu*, Xin Zhang*, Zhengyan Wu*. Fabrication of a high-performance fertilizer to control the loss of water and nutrient using micro/nano networks. ACS Sustainable Chemistry & Engineering 2015, 3, 645-653.
 
6. Na Jiang, Dongqing Cai, Lulu He, Naiqin Zhang, Han Wen*, Xin Zhang*, Zhengyan Wu*. ACS Sustainable Chemistry & Engineering 2015, 3, 374-380.
 
7. Qiulin Yue, Shiquan Xiong, Dongqing Cai, Zhengyan Wu*, Xin Zhang*. Facile and quantitative electrochemical detection of yeast cell apoptosis. Scientific Reports 2014, 4:4373.
 
8. Guilong Zhang, Junlan Gao, Junchao Qian, Dongqing Cai, Kang Zheng, Zhiwu Yu, Junfeng Wang, Kai Zhong*, Xin Zhang*, Zhengyan Wu*. A multifunctional magnetic composite material as a drug delivery system and a magnetic resonance contrast agent. Particle & Particle Systems Characterization 2014, 31, 976-984.
 
9. Guilong Zhang, Minglei Yang, Dongqing Cai, Kang Zheng, Xin Zhang, Lifang Wu*, Zhengyan Wu*. Composite of functional mesoporous silica and DNA: An enzyme-responsive controlled release drug carrier system. ACS Applied Materials & Interfaces 2014, 6, 8042-8047.
 
10. Yunfeng Zong, Junlan Gao, Huiyun Feng, Beijiu Cheng, Xin Zhang*. Toxicity of 7-ketocholesterol on lethality, growth, reproduction, and germline apoptosis in the nematode Caenorhabditis elegans. Journal of Toxicology and Environmental Health, Part A 2014, 77, 716-723.
 
11. Shiquan Xiong, Junjie Cheng, Lulu He, Min Wang, Xin Zhang*, Zhengyan Wu*. Detection of di(2-ethylhexyl) phthalate through graphene-β-Cyclodextrin composites by electrochemical impedance spectroscopy. Analytical Methods 2014, 6, 1736-1742.
 
12. Junlan Gao, Qiulin Yue, Yishun Ji, Beijiu Cheng, Xin Zhang*. Novel synthesis strategy for preparation of individual phytosterol oxides, Journal of Agricutural and Food Chemistry 2013, 61, 982-988.
 
13. Dongqing Cai, Longhai Wang, Xin Zhang*, Zhengyan Wu*. Controlling pesticide loss by natural porous micro/nano composites: straw ash-based biochar and biosilica. ACS Applied Materials & Interfaces 2013, 5, 9212-9216.
 
14. Qiulin Yue, Xiuhong Zhou, Qianli Leng, Lele Zhang, Beijiu Cheng, Xin Zhang*. 7-Ketocholesterol-induced caspase-mediated apoptosis in Saccharomyces cerevisiae. FEMS Yeast Research 2013, 13, 796-803.
 
15. Xin Zhang, Hui Pan, Bonnie Peng, Donald F. Steiner, John E. Pintar, Lloyd D. Fricker*. Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis. Journal of Neurochemistry 2010, 112, 1168-1179.
 
16. Denise A. Berti, Cain Morano, Lilian C. Russo, Leandro M. Castro, Fernanda M. Cunha, Xin Zhang, Juan Sironi, Clécio F. Klitzke, Emer S. Ferro, Lloyd D. Fricker*. Analysis of intracellular substrates and products of thimet oligopeptidase (EC 3.4.24.15) in human embryonic kidney 293 cells. Journal of Biological Chemistry 2009, 284, 14105-14116.
 
17. Xin Zhang, Fan-Yun Che, Iryna Berezniuk, Kemal Sonmez, Lawrence Toll, Lloyd D. Fricker*. Peptidomics of Cpefat/fat mouse brain regions: Implications for neuropeptide processing. Journal of Neurochemistry 2008, 107, 1596-1613.
 
18. Cain Morano, Xin Zhang (co-first author), Lloyd D. Fricker*. Multiple isotopic labels for quantitative mass spectrometry. Analytical Chemistry 2008, 80, 9298–9309.
 
19. Fa-yun Che, Xin Zhang, Iryna Berezniuk, Myrasol Callaway, Jihyeon Lim, Lloyd D. Fricker*. Optimization of neuropeptide extraction from the mouse hypothalamus. Journal of Proteome Research 2007, 6, 4667-4676.
 
20. Xin Zhang, Diane Julien-David, Michel Miesch, Francis Raul, Philippe Geoffroy, Dalal Aoudé-Werner, Saïd Ennahar, Eric Marchioni*. Quantitative analysis of β-sitosterol oxides in vegetable oils induced by natural sunlight, artificially generated ultraviolet light and irradiation. Journal of Agricutural and Food Chemistry 2006, 54, 5410-5415.
 
21. Xin Zhang, Amandine Cambrai, Michel Miesch, Stamatiki Roussi, Francis Raul, Dalal Aoudé-Werner, Eric Marchioni*. Separation of 5- and 7-phytosterols by adsorption chromatography and semi-preparative RP-HPLC for quantitative analysis of phytosterols in foods. Journal of Agricutural and Food Chemistry 2006, 54, 1196-1202.
 
22. S. Roussi, A Winter, F Fosse, D Werner, X Zhang, E Marchioni, P Geoffroy, M Miesch, F Raul*. Different apoptotic mechanisms are involved in the antiproliferative effects of 7β-hydroxysitosterol and 7β-hydroxycholesterol. Cell Death and Differentiation 2005, 12, 128-135.
 
23. Xin Zhang, Diane Julien-David, Michel Miesch, Philippe Geoffroy, Francis Raul, Stamatiki Roussi, Dalal Aoudé-Werner, Eric Marchioni*. Identification and quantitative analysis of β-sitosterol oxides in vegetable oils by capillary gas chromatography-mass spectrometry. Steroids 2005, 70, 896-906.
 
24. Xin Zhang, Philippe Geoffroy, Michel Miesch, Diane Julien-David, Francis Raul, Dalal Aoudé-Werner, Eric Marchioni*. Gram-scale chromatographic purification of β-sitosterol: Synthesis and characterization of β-sitosterol oxides. Steroids 2005, 70, 886-895.